CBD OIL – How does Cannabidiol work?

Written by Jane

April 20, 2021

CBD, Cannabidiol, is a natural chemical found in the Marijuana, Cannabis sativa plant. CBD is used for multiple illnesses, such as seizure disorder (epilepsy), anxiety, pain, a muscle disorder called dystonia, Parkinson disease, Crohn disease, and many other conditions (WebMD). Studies have been conducted on Exercise and CBD consumption and its benefits, Progress in Neuro-Psychopharmacology, and Biological Psychiatry.

Scientific Evidence & Published Articles 2021

Over 100 molecular compositions known as cannabinoids have been identified in the Cannabis sativa plant.  Tetrahydrocannabinol also referred to as THC, a compound effectively demonstrated in animal studies, human studies, and in vitro studies

“Pharmacological Properties of∆(9)-Tetrahydrocannabinol: A Review.” (2021).

THC is the principal psychoactive constituent of cannabis. Although the chemical formula for THC describes multiple isomers, the term THC usually refers to the Delta-9-THCWhile delta-9-tetrahydrocannabinol (THC) is the major active ingredient in marijuana, cannabidiol is also obtained from hemp, which contains only very small amounts of THC, “Safety and tolerability of natural and synthetic cannabinoids in adults aged over 50 years: A systematic review and meta-analysis.” PLoS medicine 18.3 (2021)

Overall, CBD, Cannabidiol is well tolerated and has a good safety profile. In the Safety and Tolerability Study of real-world experience in observational studies, registries, and case reports, compiles safety and tolerability data from all published observational studies, registry analyses, and case reports which investigated nabiximols oromucosal spray for treatment of spasticity and/or chronic pain.

Declaration of Interest Disclaimer

The authors of the 2021 report of Safety and Tolerability Study of real-world experience in observational studies, registries, and case reports, publish they have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or conflict with the subject matter or materials discussed in this manuscript apart from those disclosed. Why is this important? Because very few journal articles and research studies published in English disclose their financial, political, and special interest position.

Academic Research & Peer Reviewed Scholars

In 1843 the first scientific report in the Western world on the medicinal use of cannabis came from an Irish physician, Sir William B. O’Shaughnessy, who noted that hemp “possesses, in small doses, an extraordinary power of stimulating the digestive organs, exciting the cerebral system, of acting also on the generative apparatus.” O’Shaughnessy WB. On the preparations of the Indian Hemp, or Gunjah: Cannabis indica their effects on the animal system in health, and their utility in the treatment of tetanus and other convulsive diseases. Prov Med J Retrosp Med Sci. 1843. In 1896 the first successful attempt to identify a cannabis constituent was achieved by Wood ET, who isolated cannabinol from the exuded resin of Indian Hemp Cannabinoid Chemistry Overview. 

Ancient Chinese archeology, dating back to 2700 BC and tablets written by the Sumerian and Akkadian peoples as old as 1800 BC provides historical evidence that CBD has stood the test of time. In Western society, it is seen as risky and unreliable but it is largely due to the lack of support (funding) received by universities. Fortunately, there are many reliable international institutions that provide

Department of Medicinal Chemistry and Natural Products, Medical Faculty, The Hebrew Universityof Jerusalem, Ein Kerem Campus,91120 Jerusalem, Israel

Journal of Pharmacy and Pharmacology, Cannabinoid compounds in South African cannabis sativa

L. Rambam Maimonides Medical Journal, Ben-Zeev, Bruria.

Note: “Western Pharmaceutical” is defined as a system in which medical doctors and other healthcare professionals (such as nurses, pharmacists, and therapists) treat symptoms and diseases using drugs, radiation, or surgery Quote from National Cancer Institute:http://www.cancer.gov For this reason, many believe that there is little funding for furthering the research of CBD, Cannabinold, health benefits.

Written by Jane

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